Preheat your oven to 350°F (175°C).
Cook the macaroni according to package instructions until al dente, then drain.
In a large saucepan, melt the butter over medium heat.
Whisk in flour and cook for about 1 minute, stirring constantly to create a roux.
Gradually whisk in the milk, ensuring there are no lumps, and cook until thickened.
Stir in the cheddar and mozzarella cheeses until melted and smooth.
Add garlic powder, mustard powder, salt, and pepper; stir to combine.
Combine the cooked macaroni with the cheese sauce, stirring gently to coat.
Transfer the mixture to a greased baking dish and sprinkle breadcrumbs evenly on top.
Bake in the preheated oven for 25-30 minutes, or until the top is golden and bubbly.
Let it cool for a few minutes before serving.