Preheat your oven to 350°F (175°C).
In a mixing bowl, combine the shredded cheddar, cream cheese, flour, garlic powder, and salt until well blended.
Scoop tablespoon-sized portions of the dough and roll them into balls.
Place the dough balls on the prepared baking sheet, leaving some space between them.
Using your thumb or a small spoon, create a well in the center of each dough ball.
Bake in the preheated oven for 15-18 minutes, or until golden brown.
Remove from the oven and cool slightly before filling the thumbprints with hot pepper jelly.
Serve warm for the best flavor and texture experience.