Preheat the oven to 400°F (200°C).
Marinate the chicken in buttermilk for at least 30 minutes.
Combine flour, garlic powder, onion powder, paprika, salt, and black pepper in a shallow dish.
Place panko breadcrumbs in a separate shallow dish.
Remove the chicken from buttermilk, letting excess drip off, then coat in the flour mixture.
Dredge the flour-coated chicken in panko breadcrumbs, ensuring an even coating.
Arrange the coated chicken pieces on a greased baking sheet.
Spray the top of the chicken lightly with cooking spray or drizzle with oil.
Bake in the preheated oven for 20-25 minutes, or until golden brown.
Let the chicken rest for a few minutes before serving.