Preheat your oven to 400°F (200°C).
In a large skillet over medium heat, cook the ground turkey until browned, about 5-7 minutes. Drain any excess fat.
Add the diced onion to the skillet and sauté until it becomes translucent, about 3-4 minutes.
Stir in the frozen mixed vegetables, cream of mushroom soup, milk, garlic powder, onion powder, black pepper, salt, and Worcestershire sauce. Mix until well combined and heated through, about 5 minutes.
Transfer the turkey mixture to a greased 9x13-inch baking dish, spreading it evenly.
Arrange the frozen tater tots on top of the turkey mixture in an even layer. Sprinkle the shredded cheddar cheese over the tater tots.
Bake in the preheated oven for 30-35 minutes, or until the tater tots are golden brown and crispy.
Allow to cool for a few minutes before serving. Enjoy your Turkey Tater Tot Hotdish!